[UPDATED] I hated how that hand was drawn; that was the stock-rote-memorized way I drew hands when I was a kid. I'm a grown man now! Plus this is a lot more visceral, grippy, gross. If I do paint this, I'd like to ask a calligrapher to collab on the type. I have one in mind.
Just an idea...sketching lots of little things working up to some paintings.
Medusa's story is really tragic, so I'm not sure if the leering mouth is quite right for it. Or maybe I should drop the history lesson at the bottom and just have it be a scary-face picture.
If you're at all interested, here's a flashy History Channel version of the story.